Scientific representation

Challenges and benefits of universal detection in modern liquid chromatography

Time: Wednesday, April 19, 2023 (16:20 - 16:45)

Venue: The 2nd floor, SECC center, 799 Nguyen Van Linh Street, Dist. 7, HCMC

Dr. Paul Gamache


  • Over 30 years of experience within the analytical instrument industry with a primary focus on development of instrumentation and techniques based on liquid chromatography for clinical, biomedical research, chemical, food and beverage, nutrition and pharmaceutical applications
  • Analytical chemist who joined Thermo Fisher Scientific in 2011 through acquisition of Dionex Corporation
  • Published over 50 scientific articles and book chapters
  • Helped to lead development of first and second generation Corona CAD products
  • Editor and contributing author to the book “Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques” published in 2017 by John Wiley & Sons, Inc
  • Member of the ASTM International committee on Nano-enabled Medical Products


  • 2011 to Present: Director, Research and Development — Thermo Fisher Scientific: Responsible for development of analytical technologies with primary focus on charged aerosol detection (CAD) and electrochemical detection (ECD) for liquid chromatography
  • 2009 to 2011: Director, Life Science Research — ESA, A Dionex Company: Lead team responsible for developing new solutions based on charged aerosol, electrochemical, mass spectrometric and other technologies
  • 2004 to 2009: Vice President, Research and Applications — ESA Biosciences: Led development of first US FDA 510K cleared in vitro diagnostic test for 25-HydroxyVitamin D in serum and plasma; Principle author and co-awardee of an NIH Metabolomics Roadmap research grant, which involved development of technologies based on the combined use of electrochemistry (EC) and mass spectrometry (MS)
  • 1979 to 2004: Various positions including Applications Director and Senior Scientist – ESA Inc


  • 1982: Master of Science, Clinical Chemistry, Northeastern University, Boston, MA, USA
  • 1978: Bachelor of Science Biology, University of Massachusetts, Dartmouth, MA, USA

Selected Patents and References:

  • Yim AD, Gamache PH, McCarthy RS. Nebulizer for charged aerosol detection (CAD) system. Google Patents; 2021
  • Gamache PH. Methods and systems for detection of non-volatile solutes. Google Patents; 2019.
  • Gamache PH. Book Editor. Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques: John Wiley & Sons; 2017.
  • Gamache PH, Kaufman SL. Principles of Charged Aerosol Detection. Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques. 2017:1-65.
  • Gamache PH, McCarthy RS, Freeto SM, Asa DJ, Woodcock MJ, Laws K, et al. HPLC analysis of nonvolatile analytes using charged aerosol detection. LC GC Europe. 2005;18(6):345.
  • Gamache, P.H., D.F. Meyer, M.C. Granger, and I.N. Acworth, Metabolomic applications of electrochemistry/mass spectrometry. J Am Soc Mass Spectrom, 2004. 15(12): p. 1717-26
  • Gamache, P., S. Freeto, and I. Acworth, Coulometric array HPLC analysis of lipid-soluble vitamins and antioxidants. American Clinical Laboratory, 1999. 18: p. 18-19
  • Gamache, P., T. Maher, K. Setchell, T. Wu, and I. Acworth, Sensitive analysis of phytoestrogens in animal tissue by HPLC with coulometric array detection. American Journal of Clinical Nutrition, 1998. 68
  • Gamache, P., E. Ryan, and I.N. Acworth, Analysis of phenolic and flavonoid compounds in juice beverages using high-performance liquid chromatography with coulometric array detection. Journal of Chromatography A, 1993. 635(1): p. 143-150
  • Gamache, P., E. Ryan, C. Svendsen, K. Murayama, and I.N. Acworth, Simultaneous measurement of monoamines, metabolites and amino acids in brain tissue and microdialysis perfusates. J Chromatogr, 1993. 614(2): p. 213-20
  • Gamache, P.H., M.L. Kingery, and I.N. Acworth, Urinary metanephrine and normetanephrine determined without extraction by using liquid chromatography and coulometric array detection. Clin Chem, 1993. 39(9): p. 1825-30